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Authorities believe the animals were probably stolen to be sold on the black market and have urged the public to alert authorities if any are sighted. Consider risk of severe and sometimes irreversible toxicity if used for prolonged periods in treatment of rheumatoid arthritis. a See Cautions. Park and K. Park: Textbook of Preventive and Social Medicine. 10. Yash Pal Bedi: A Handbook of Hygiene and Public Health. 11. Material published by Ministry of Health, Family Planning and Urban Development, Department of Family Planning. Paper BPH 15 PHARMACOLOGY-I THEORY Total Teaching Hours: 50 1. General Pharmacology i Definition, scope and branches of pharmacology. Historical development with special reference to India. ii Routes of drugs administration and drug delivery systems. iii Dynamics of absorption, distribution and excretion of drugs. iv Basic pharmacokinetic parameters employed in the use of drugs, their bioavailability and biotransformations, metabolizing enzymes as targets of drugs action induction and inhibition. v Mechanisms of drugs action, drug receptors and cellular signaling systems. vi Drug antagonism and synergism. vii Drug dependence and related conditions. viii Adverse drug effects and their monitoring, Iatrogenic diseases. ix Pharmacogenomics. 2. Pharmacology of Autonomic Nervous System i Cholinergic receptors, cholinergic drugs parasympathomimetics, cholinomimetics, anticholinesterases. ii Anticholinergic drugs. iii Adrenoceptors, sympathomimetics, adrenoceptors blockers. iv Drugs action on autonomic ganglia ganglionic stimulants, ganglion blocking agents. v Neuromuscular blocking agents and centrally acting muscle relaxants. 3. Autocoids i Histamine, Antihistaminics. ii Serotonin, agonists and antagonists. iii Arachidonic acid metabolites.
Radioactively tagged Chloroquine administered intravenously to pregnant pigmented CBA mice passed rapidly across the placenta and accumulated selectively in the melanin structures of the fetal eyes. It was retained in the ocular tissues for five months after the drug had been eliminated from the rest of the body 2. There are no adequate and well-controlled studies evaluating the safety and efficacy of Chloroquine in pregnant women. Usage of Chloroquine during pregnancy should be avoided except in the suppression or treatment of malaria when in the judgment of the physician the benefit outweighs the potential risk to the fetus.
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